Issue 20, 2021

Allosteric binding of sodium deoxycholate by a bis(β-cyclodextrin)-2,2′-bipyridine receptor

Abstract

The synthesis of a new positively allosteric bis(β-cyclodextrin) receptor 1 is described. The binding affinity of the receptor in its “on” and “off” states towards sodium deoxycholate in aqueous solution was studied by means of isothermal titration calorimetry and NMR spectroscopic titrations. The allosteric effect amounts to a more than 18-fold increase of the binding constant of receptor 1 towards the substrate upon addition of a zinc(II) phenanthroline complex that acts as an effector for the allosteric 2,2′-bipyridine motif.

Graphical abstract: Allosteric binding of sodium deoxycholate by a bis(β-cyclodextrin)-2,2′-bipyridine receptor

Supplementary files

Article information

Article type
Research Article
Submitted
06 Ago 2021
Accepted
12 Ago 2021
First published
16 Ago 2021

Org. Chem. Front., 2021,8, 5810-5820

Allosteric binding of sodium deoxycholate by a bis(β-cyclodextrin)-2,2′-bipyridine receptor

G. Hoffrichter and A. Lützen, Org. Chem. Front., 2021, 8, 5810 DOI: 10.1039/D1QO01173A

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