Asymmetric synthesis of oxazolines bearing α-stereocenters through radical addition–enantioselective protonation enabled by cooperative catalysis

Abstract

An efficient radical conjugate addition/enantioselective protonation process was developed for N-aryl glycines and alkenyl oxazolines enabled by the cooperative photoredox catalysis and chiral phosphoric acid catalysis, which generated a series of chiral oxazolines bearing an α-stereocenter with high enantioselectivities. The facile transformations of the chiral oxazoline products into enantioenriched lactams and γ-amino esters bearing α-stereocenters demonstrate the value of this method.