Issue 16, 2021

Recent advances in the copper-catalyzed aerobic Csp3–H oxidation strategy

Abstract

The interplay between copper catalysts and molecular oxygen provides the opportunity to control the promiscuous catalytic behaviors in aerobic Csp3–H bond oxidations without using stoichiometric amounts of oxidants. This mini-review aims to cover the Cu-catalyzed aerobic benzylic and α-carbonyl Csp3–H oxidations and that of the carbon next to an amine group in the past five years. The development of tandem multicomponent reactions employing aerobic Csp3–H bond oxidations will be discussed to highlight the controlled catalyst behaviors and the catalyst interactions between multiple reaction components.

Graphical abstract: Recent advances in the copper-catalyzed aerobic Csp3–H oxidation strategy

Associated articles

Article information

Article type
Review Article
Submitted
15 Jan 2021
Accepted
19 Mac 2021
First published
19 Mac 2021

Org. Biomol. Chem., 2021,19, 3569-3583

Recent advances in the copper-catalyzed aerobic Csp3–H oxidation strategy

H. Y. Kim and K. Oh, Org. Biomol. Chem., 2021, 19, 3569 DOI: 10.1039/D1OB00081K

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