Issue 39, 2021

Electrochemical synthesis of sulfamides

Abstract

Herein we demonstrate the first electrochemical synthesis protocol of symmetrical sulfamides directly from anilines and SO2 mediated by iodide. Sulfamides are an emerging functional group in drug design. Highlights are the direct use of SO2 from a stock solution and no necessity of any supporting electrolyte. Overall, the reaction has been demonstrated for 15 examples with yields up to 93%.

Graphical abstract: Electrochemical synthesis of sulfamides

Supplementary files

Article information

Article type
Communication
Submitted
16 Mac 2021
Accepted
12 Apr 2021
First published
12 Apr 2021

Chem. Commun., 2021,57, 4775-4778

Electrochemical synthesis of sulfamides

S. P. Blum, L. Schäffer, D. Schollmeyer and S. R. Waldvogel, Chem. Commun., 2021, 57, 4775 DOI: 10.1039/D1CC01428E

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