Niklas H. Fischer, Daniel S. Nielsen, Daniel Palmer, Morten Meldal and Frederik Diness
Chem. Commun., 2021,57, 895-898
DOI:
10.1039/D0CC06018F,
Communication
Solid-phase synthesis of peptides (SPPS) with release through formation of C-terminal γ-, δ-, or ε-lactams is presented. The natural products ciliatamide A and C were synthesized in up to 90% yield. Peptides carrying C-terminal lactams were shown to possess increased bio-stability and comparable biological activity as compared to the parent non-lactamized peptide amides.
