Seylan Ayan, Adrian M. Rotaru, Esther G. Kaye, Gabrielle Juneau, Sunit Das, Christopher J. Wilds and Andrew A. Beharry
Org. Biomol. Chem., 2024,22, 2749-2753
Abstract
A fluorescent chemosensor for O6-methylguanine DNA methyltransferase derived from a non-pseudosubstrate, covalent inhibitor.
William Copp, Ashkan Karimi, Tianxiao Yang, Alba Guarné and Nathan W. Luedtke
Chem. Commun., 2024,60, 1156-1159
Abstract
Alkylation at the O6 position of guanine is a common and highly mutagenic form of DNA damage. Here, dynamic changes in fluorescence from a molecular rotor base analogue are used to track O6 alkylation and repair in duplex DNA.
Reyhan Dilsu Colpan, Ellie B. Ward, Dongling Zhang, Binbing Ling, Umar Iqbal, Maria Moreno, Neil R. Thomas, Lyudmila Turyanska and Tracey D. Bradshaw
Nanoscale Adv., 2025,7, 6808-6818
Abstract
Co-encapsulation of PbS quantum dots and temozolomide within apoferritin enables enhanced cancer-selective therapeutic and imaging capability in glioblastoma cells.
Malcolm F. G. Stevens and Richard T. Wheelhouse
RSC Chem. Biol., 2023,4, 736-741
From themed collection:
Medicinal Chemistry Small Molecule Probes
Abstract
Are we there yet? The 40 year quest for a new temozolomide.
Maria Letizia Cassioli, Michael Fay, Lyudmila Turyanska, Tracey D. Bradshaw, Neil R. Thomas and Anca Pordea
RSC Adv., 2024,14, 14008-14016
Abstract
Copper complexes and temozolomide can be co-encapsulated within apoferritin.