Issue 39, 2016

Co(acac)2/O2-catalyzed oxidative isocyanide insertion with 2-vinylanilines: efficient synthesis of 2-aminoquinolines

Abstract

A series of 2-aminoquinolines were afforded by Co(acac)2 catalyzed isocyanide insertion with 2-vinylanilines under an O2 atmosphere. This reaction not only uses low toxicity Co(acac)2 as the catalyst and oxygen as the oxidant, but also allows the construction of new C(sp2)–C(sp2) and C(sp2)–N bonds in a single-step.

Graphical abstract: Co(acac)2/O2-catalyzed oxidative isocyanide insertion with 2-vinylanilines: efficient synthesis of 2-aminoquinolines

Supplementary files

Article information

Article type
Paper
Submitted
03 Kol 2016
Accepted
09 Ube 2016
First published
11 Ube 2016

RSC Adv., 2016,6, 32467-32470

Co(acac)2/O2-catalyzed oxidative isocyanide insertion with 2-vinylanilines: efficient synthesis of 2-aminoquinolines

P. Xu, T. Zhu, T. Wei, S. Wang and S. Ji, RSC Adv., 2016, 6, 32467 DOI: 10.1039/C6RA03216H

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