Issue 1, 2016

Copper-catalyzed cycloaddition between hydrogen phosphonates and activated alkenes: synthesis of phosphonoisoquinolinediones

Abstract

A new, general method for the synthesis of phosphonoisoquinolinediones has been achieved via copper-catalyzed phosphonation–cyclization of various methacryloylbenzamides with P(O)H compounds. This transformation allows the direct formation of a P–C bond and the construction of an isoquinolinedione ring in one reaction.

Graphical abstract: Copper-catalyzed cycloaddition between hydrogen phosphonates and activated alkenes: synthesis of phosphonoisoquinolinediones

Supplementary files

Article information

Article type
Communication
Submitted
28 Mph 2015
Accepted
11 Tsh 2015
First published
15 Tsh 2015

RSC Adv., 2016,6, 303-306

Copper-catalyzed cycloaddition between hydrogen phosphonates and activated alkenes: synthesis of phosphonoisoquinolinediones

J. Wu, Y. Gao, X. Zhao, L. Zhang, W. Chen, G. Tang and Y. Zhao, RSC Adv., 2016, 6, 303 DOI: 10.1039/C5RA22570A

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