Issue 4, 2015

TEMP and copper cocatalyzed oxygenation of ketones with molecular oxygen: chemoselective synthesis of α-ketoesters

Abstract

A novel and practical method for the synthesis of α-ketoesters through TEMP and copper cocatalyzed chemoselective oxidative coupling of commercially available methyl ketones with alcohols is developed. Mild conditions and broad substrate scope make this chemistry an efficient tool for the late-stage modification of bioactive compounds. Detailed mechanistic studies demonstrate a novel mechanism involving an organocatalytic cycle and SET process. The oxygenation process with molecular oxygen enables this transformation.

Graphical abstract: TEMP and copper cocatalyzed oxygenation of ketones with molecular oxygen: chemoselective synthesis of α-ketoesters

Supplementary files

Article information

Article type
Research Article
Submitted
26 Phe 2015
Accepted
09 Kol 2015
First published
11 Kol 2015

Org. Chem. Front., 2015,2, 354-359

TEMP and copper cocatalyzed oxygenation of ketones with molecular oxygen: chemoselective synthesis of α-ketoesters

X. Huang, X. Li, M. Zou, J. Pan and N. Jiao, Org. Chem. Front., 2015, 2, 354 DOI: 10.1039/C5QO00028A

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