Issue 20, 2023

Direct coupling of inert C–H bonds in NHC organocatalysis

Abstract

Direct coupling of inert C–H bonds by N-heterocyclic carbenes (NHCs) represents a fascinating area of research in organocatalysis. Recently, several notable studies have disclosed the potential of NHCs to directly functionalize latent C–H bonds of diverse simple molecules (e.g., ethers, amines, and arenes). These methodologies offer straightforward and efficient routes for C–C bond-forming transformations by diminishing the need for prefunctionalization manipulations of inert C–H bonds, allowing for the synthesis of a broad range of high value-added functional ketone molecules. Consequently, this highlight aims to present the latest advancements in NHC organocatalysis, specifically focusing on direct coupling functionalization of inert C–H bonds involving the electron or proton transfer process (ET/PT pathways) and hydrogen atom transfer pathway (HAT pathway).

Graphical abstract: Direct coupling of inert C–H bonds in NHC organocatalysis

Article information

Article type
Chemistry Frontiers
Submitted
21 jul 2023
Accepted
16 avg 2023
First published
12 sep 2023

Org. Chem. Front., 2023,10, 5291-5295

Direct coupling of inert C–H bonds in NHC organocatalysis

H. Wang, F. Su, Y. Wang, X. Wu and Y. R. Chi, Org. Chem. Front., 2023, 10, 5291 DOI: 10.1039/D3QO01129A

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