Issue 20, 2022

Recent advances in the cascade reactions of enynols/diynols for the synthesis of carbo- and heterocycles

Abstract

Carbo- and heterocycles frequently serve as crucial scaffolds in drugs, natural products, fine chemicals, and biologically and pharmaceutically active compounds. Consequently, the development of general, practical, and efficient synthetic approaches for their preparation has attracted considerable attention from organic chemists. In the past few decades, the cascade cyclization of enynols and diynols has become a powerful tool to construct various frameworks. In this review, we highlight recent advances in this field toward the efficient construction of carbo- and heterocycles. According to the type of substrates, these transformations can be divided into two categories: (1) cascade reactions of enynols for the synthesis of carbo- and heterocycles; and (2) cascade reactions of diynols for the synthesis of carbo- and heterocycles.

Graphical abstract: Recent advances in the cascade reactions of enynols/diynols for the synthesis of carbo- and heterocycles

Article information

Article type
Review Article
Submitted
17 jul 2022
Accepted
08 sep 2022
First published
09 sep 2022

Org. Chem. Front., 2022,9, 5643-5674

Recent advances in the cascade reactions of enynols/diynols for the synthesis of carbo- and heterocycles

S. Jiang, H. Ma, R. Yang, X. Song and Q. Xiao, Org. Chem. Front., 2022, 9, 5643 DOI: 10.1039/D2QO01154A

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