Issue 20, 2022
From the journal:

Organic Chemistry Frontiers

Lewis acid-promoted cyclizations of o-alkyloxyphenyl-substituted ynamides to construct 2-amidobenzofurans†

Hui Xu,a   Yangpeng Liu,a   Lixia Ding,a   Xiao-Na Wang ORCID logo *a  and  Junbiao Chang*a  

* Corresponding authors

a Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, P. R. China
E-mail: wangxn@zzu.edu.cn, changjunbiao@zzu.edu.cn

Abstract

Lewis acid-promoted cyclizations of o-alkyloxyphenyl-substituted ynamides are described for the general construction of medicinally relevant 2-amidobenzofurans. A diverse array of 3-acyl-2-amidobenzofurans could be effectively constructed via a SnCl4-promoted intermolecular reaction. And the 3-unsubstituted 2-amidobenzofurans could be obtained efficiently through a ZnCl2-promoted intramolecular reaction.

Graphical abstract: Lewis acid-promoted cyclizations of o-alkyloxyphenyl-substituted ynamides to construct 2-amidobenzofurans

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Article information

DOI
https://doi.org/10.1039/D2QO01246D
Article type
Research Article
Submitted
03 Aug 2022
Accepted
30 Aug 2022
First published
01 Sep 2022

Org. Chem. Front., 2022,9, 5637-5642

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Lewis acid-promoted cyclizations of o-alkyloxyphenyl-substituted ynamides to construct 2-amidobenzofurans

H. Xu, Y. Liu, L. Ding, X. Wang and J. Chang, Org. Chem. Front., 2022, 9, 5637 DOI: 10.1039/D2QO01246D

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