Issue 8, 2022

Recent advances in transition metal-catalyzed heteroannulative difunctionalization of alkenes via C–H activation for the synthesis of heterocycles

Abstract

Heterocyclic compounds are the fundamental structural motifs distributed in natural products, pharmaceuticals and biologically active compounds. Thus, there is increasing interest in the development of novel synthetic strategies for the construction of these privileged motifs. Recently, alkenes have emerged as sustainable, abundant, versatile two-carbon synthons and display great potential in the synthesis of heterocycles. Along these lines, transition metal-catalyzed heteroannulative difunctionalization of alkenes via C–H activation has been developed as a practical and powerful synthesis route towards heterocyclic frameworks with high atom- and step-economy. In this review, we highlight the recent advancements in the field of transition metal-catalyzed C–H annulation of alkenes for the preparation of heterocycles such as indolines, isocoumarins, benzoxepines, benzoazepines, tetrahydroisoquinolines, lactams, dihydropyridinones, isoquinolinones, and dihydrophosphaisocoumarins, based on different metal catalysts including palladium, rhodium, ruthenium, and cobalt. Moreover, the related reaction mechanisms and significant applications are also discussed.

Graphical abstract: Recent advances in transition metal-catalyzed heteroannulative difunctionalization of alkenes via C–H activation for the synthesis of heterocycles

Article information

Article type
Review Article
Submitted
18 jan 2022
Accepted
05 mar 2022
First published
09 mar 2022

Org. Chem. Front., 2022,9, 2256-2279

Recent advances in transition metal-catalyzed heteroannulative difunctionalization of alkenes via C–H activation for the synthesis of heterocycles

J. Liu, X. Xiao, Y. Lai and Z. Zhang, Org. Chem. Front., 2022, 9, 2256 DOI: 10.1039/D2QO00081D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements