Issue 15, 2022

Structurally rigidified cobalt bis(dicarbollide) derivatives, a chiral platform for labelling of biomolecules and new materials

Abstract

We report the difunctional modification of an anionic cobalta bis(dicarbollide)(1) cluster with a B(8,8′)-oxygen bridging unit that provides structural rigidity and an organic alkylazide substituent(s) on the carbon atoms of the metallacarborane cage. These ions present a good binding motif for incorporation into organic molecules using Huisgen-Sharpless (2+3) cycloaddition reactions. In addition, the compounds are chiral, as verified by separation of enantiomers using HPLC on chiral stationary phases (CSPs) and provide a high electrochemical peak in the window located outside of typical signals of biomolecules.

Graphical abstract: Structurally rigidified cobalt bis(dicarbollide) derivatives, a chiral platform for labelling of biomolecules and new materials

Supplementary files

Article information

Article type
Communication
Submitted
10 dec 2021
Accepted
18 jan 2022
First published
18 jan 2022

Chem. Commun., 2022,58, 2572-2575

Structurally rigidified cobalt bis(dicarbollide) derivatives, a chiral platform for labelling of biomolecules and new materials

S. El Anwar, L. Pazderová, D. Bavol, M. Bakardjiev, Z. Růžičková, O. Horáček, L. Fojt, R. Kučera and B. Grűner, Chem. Commun., 2022, 58, 2572 DOI: 10.1039/D1CC06979A

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