Issue 20, 2019

Visible-light-induced radical hydrodifluoromethylation of alkenes

Abstract

Described here is the radical-mediated hydrodifluoromethylation of alkenes that occurs under transition-metal-free conditions by using the phosphonium salt [Ph3P+CF2H]Br under the irradiation of 26 W household compact fluorescent light. The reaction lends itself to a convenient protocol for the installation of a C–CF2H bond while maintaining good functional group tolerance.

Graphical abstract: Visible-light-induced radical hydrodifluoromethylation of alkenes

Supplementary files

Article information

Article type
Research Article
Submitted
21 jul 2019
Accepted
04 sep 2019
First published
05 sep 2019

Org. Chem. Front., 2019,6, 3580-3583

Visible-light-induced radical hydrodifluoromethylation of alkenes

J. Yu, J. Lin, Y. Cao and J. Xiao, Org. Chem. Front., 2019, 6, 3580 DOI: 10.1039/C9QO00919A

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