Issue 34, 2016

How cocrystals of weakly basic drugs and acidic coformers might modulate solubility and stability

Abstract

Cocrystals of a weakly basic drug (nevirapine) with acidic coformers are shown to alter the solubility dependence on pH, and to exhibit a pHmax above which a less soluble cocrystal becomes more soluble than the drug. The cocrystal solubility advantage can be dialed up or down by solution pH.

Graphical abstract: How cocrystals of weakly basic drugs and acidic coformers might modulate solubility and stability

Supplementary files

Article information

Article type
Communication
Submitted
28 jan 2016
Accepted
29 mar 2016
First published
29 mar 2016

Chem. Commun., 2016,52, 5832-5835

Author version available

How cocrystals of weakly basic drugs and acidic coformers might modulate solubility and stability

G. Kuminek, N. Rodríguez-Hornedo, S. Siedler, H. V. A. Rocha, S. L. Cuffini and S. G. Cardoso, Chem. Commun., 2016, 52, 5832 DOI: 10.1039/C6CC00898D

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