Issue 11, 2015

Catalyst-free cross-coupling of N-tosylhydrazones with chromium(0) Fischer carbene complexes: a new approach to diarylethanone

Abstract

Cross-coupling of N-tosylhydrazones with chromium Fischer carbene complexes under catalyst-free conditions has been developed. This protocol employs stable carbene complexes and reactive diazo compounds, which are in situ generated from N-tosylhydrazones. Through hydrolysis of the initially formed methyl enolate products, the diarylethanone derivatives could be obtained in moderate to good yields.

Graphical abstract: Catalyst-free cross-coupling of N-tosylhydrazones with chromium(0) Fischer carbene complexes: a new approach to diarylethanone

Supplementary files

Article information

Article type
Research Article
Submitted
31 jul 2015
Accepted
28 avg 2015
First published
28 avg 2015

Org. Chem. Front., 2015,2, 1450-1456

Author version available

Catalyst-free cross-coupling of N-tosylhydrazones with chromium(0) Fischer carbene complexes: a new approach to diarylethanone

F. Hu, J. Yang, Y. Xia, C. Ma, H. Xia, Y. Zhang and J. Wang, Org. Chem. Front., 2015, 2, 1450 DOI: 10.1039/C5QO00241A

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