Issue 71, 2022

Iron-catalyzed deconstructive alkylation through chlorine radical induced C–C single bond cleavage under visible light

Abstract

Selective C–C single bond cleavage of simple compounds is a highly challenging and desired process. Herein, a chlorine radical-induced deconstructive C–C bond alkylation with alcohols and alkenes catalyzed by iron salts was reported for the first time. Readily available alcohols and various electron-deficient alkenes were tolerated. Late-stage and large-scale reactions proceed smoothly. This catalyst system shows potential for diversified deconstructive functionalization of simple C–C bonds.

Graphical abstract: Iron-catalyzed deconstructive alkylation through chlorine radical induced C–C single bond cleavage under visible light

Supplementary files

Article information

Article type
Communication
Submitted
13 jul 2022
Accepted
12 avg 2022
First published
12 avg 2022

Chem. Commun., 2022,58, 9886-9889

Iron-catalyzed deconstructive alkylation through chlorine radical induced C–C single bond cleavage under visible light

Q. Wu, W. Liu, M. Wang, Y. Huang and P. Hu, Chem. Commun., 2022, 58, 9886 DOI: 10.1039/D2CC03896J

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