Themed collection Optical Diagnosis

Welcome to the latest themed issue on the topic of Optical Diagnosis in Analyst, guest-edited by Kathleen Gough and Frédéric Leblond.

Mid-infrared microscopy is a non-destructive, quantitative and label-free spectroscopic imaging technique that, as a result of recent instrument advancements, is now at the point of enabling high-throughput automated biochemical screening of whole histology samples.

GAG profiling in live cells by micro-Raman spectroscopy.

The morphology and structure of biological nanoparticles, such as viruses, can be efficiently analysed by transmission electron microscopy (TEM).

FTIR imaging shows biochemical differences between salivary glands from control and hypertensive rats.

Mid-infrared microscopy has become a key technique in the field of biomedical science and spectroscopy. In this current study, we explore the use of a QCL infrared microscope to produce high definition, high throughput chemical images useful for the screening of biopsied colorectal tissue.

High throughput Raman spectroscopy method for rapid and accurate diagnosis of prostate cancer using liquid plasma samples.

S-FTIR and Raman microspectroscopies identify spectral markers of sensitivity/resistance to nilotinib in leukaemia cell clones.

Non-destructive near infrared spectroscopic data can be utilized for assessment of compositional and mechanical properties of engineered cartilage.

Monitoring of changes in the concentrations of the low molecular weight constituents enhanced by abundant proteins depletion.

This paper presents a procedure that digitally neutralizes the contribution of paraffin to FTIR hyperspectral images.

Infrared spectral histopathology has shown great promise as an important diagnostic tool, with the potential to complement current pathological methods.

Total Reflectance Infrared Spectroscopy (ATR-FTIR) has the potential to become a new diagnostic tool for malaria and other diseases.

We propose in this paper that protein microarrays could be analysed by infrared imaging in place of enzymatic or fluorescence labelling.

FTIR-based classification of the effect of polyphenols on a breast cancer cell line.

There has recently been significant interest within the vibrational spectroscopy community to apply quantitative spectroscopic imaging techniques to histology and clinical diagnosis.

Mid-infrared absorption and scattering properties of porcine dermis are quantified using quantum cascade laser-based goniometry.

A simple blood test for the diagnosis of Alzheimer's disease using FTIR microscopy.

The great capability of virtual staining for label-free classification of colon cancer tissue has been demonstrated via Raman spectral imaging.

The diagnostic performance of Raman spectroscopy for differentiating lichen sclerosus from other vulval conditions in fresh vulval biopsies is demonstrated.

A filter system to perform in vivo Raman spectroscopy measurements under microscope lighting for seamless integration into the surgical workflow.

Imaging with the use of Raman spectroscopy enables the characterization and distinction of live cells that were freshly isolated from murine livers.

Barrett's oesophagus (BE) is a premalignant condition that can progress to oesophageal adenocarcinoma. Fourier transform infrared (FTIR) mapping can be used to identify neoplastic Barrett's with high accuracy in a clinically applicable timeframe.