Issue 61, 2013
From the journal:

Chemical Communications

The mechanism of inhibition by H2 of H2-evolution by hydrogenases†

Vincent Fourmond,a   Carole Baffert,a   Kateryna Sybirna,b   Sébastien Dementin,a   Abbas Abou-Hamdan,a   Isabelle Meynial-Salles,c   Philippe Soucaille,c   Hervé Bottinb  and  Christophe Léger*a  

* Corresponding authors

a CNRS, Aix-Marseille Université, BIP UMR 7281, Marseille, France
E-mail: christophe.leger@imm.cnrs.fr
Web: http://bip.cnrs-mrs.fr/bip06, https://twitter.com/BIP6_Marseille
Tel: +33 4 91 16 45 29

b iBiTec-S SB2SM, LMB (UMR CNRS 8221), DSV, CEA, 91191 Gif-sur-Yvette, France

c Université de Toulouse, INSA, UPS, INP, LISBP, INRA:UMR792, CNRS:UMR 5504, 135 Avenue de Rangueil, 31077 Toulouse, France

Abstract

By analysing the results of experiments carried out with two FeFe hydrogenases and several “channel mutants” of a NiFe hydrogenase, we demonstrate that whether or not hydrogen evolution is significantly inhibited by H2 is not a consequence of active site chemistry, but rather relates to H2 transport within the enzyme.

Graphical abstract: The mechanism of inhibition by H2 of H2-evolution by hydrogenases

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Article information

DOI
https://doi.org/10.1039/C3CC43297A
Article type
Communication
Submitted
03 máj 2013
Accepted
10 jún 2013
First published
10 jún 2013

Chem. Commun., 2013,49, 6840-6842

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The mechanism of inhibition by H2 of H2-evolution by hydrogenases

V. Fourmond, C. Baffert, K. Sybirna, S. Dementin, A. Abou-Hamdan, I. Meynial-Salles, P. Soucaille, H. Bottin and C. Léger, Chem. Commun., 2013, 49, 6840 DOI: 10.1039/C3CC43297A

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