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Issue 61, 2013
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Palladium-catalyzed ortho-acylation of 2-aryl pyridine derivatives using arylmethyl amines as new acyl sources

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Abstract

A facile and efficient protocol for palladium-catalyzed ortho-acylation of 2-aryl pyridines was developed. Note that this acylation utilized arylmethyl amines as new, cheap and readily available acylation reagents and exhibited high regioselectivity for 2-aryl pyridines bearing a meta-substituent in the aryl ring moiety.

Graphical abstract: Palladium-catalyzed ortho-acylation of 2-aryl pyridine derivatives using arylmethyl amines as new acyl sources

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Article information


Submitted
22 Mar 2013
Accepted
18 Apr 2013
First published
18 Apr 2013

Chem. Commun., 2013,49, 6837-6839
Article type
Communication

Palladium-catalyzed ortho-acylation of 2-aryl pyridine derivatives using arylmethyl amines as new acyl sources

Q. Zhang, F. Yang and Y. Wu, Chem. Commun., 2013, 49, 6837
DOI: 10.1039/C3CC42106F

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