Issue 32, 2011
From the journal:

Chemical Communications

The effect of heteroatom substitution of sulfur for selenium in glucosidase inhibitors on intestinal α-glucosidase activities†‡

Razieh Eskandari,a   Kyra Jones,b   David R. Roseb  and  B. Mario Pinto*a  

* Corresponding authors

a Department of Chemistry, Simon Fraser University, Burnaby, British Colombia, Canada
E-mail: bpinto@sfu.ca
Fax: (+1)7787824860
Tel: (+1)7787824152

b Department of Biology, University of Waterloo, Waterloo, Ontario, Canada

Abstract

The synthesis of selenium analogues of de-O-sulfonated ponkoranol, a naturally occurring sulfonium-ion glucosidase inhibitor isolated from Salacia reticulata, and their evaluation as glucosidase inhibitors against two recombinant intestinal enzymes maltase glucoamylase (MGAM) and sucrase isomaltase (SI) are described.

Graphical abstract: The effect of heteroatom substitution of sulfur for selenium in glucosidase inhibitors on intestinal α-glucosidase activities

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Article information

DOI
https://doi.org/10.1039/C1CC13052H
Article type
Communication
Submitted
24 máj 2011
Accepted
28 jún 2011
First published
13 júl 2011

Chem. Commun., 2011,47, 9134-9136

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The effect of heteroatom substitution of sulfur for selenium in glucosidase inhibitors on intestinal α-glucosidase activities

R. Eskandari, K. Jones, D. R. Rose and B. M. Pinto, Chem. Commun., 2011, 47, 9134 DOI: 10.1039/C1CC13052H

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