Issue 32, 2011
From the journal:

Chemical Communications

Native and fluorescent dye-dependent single-DNA molecule microchip dynamics as measured by differential interference contrast microscopy†

Doori Oh,a   Seungah Leeb  and  Seong Ho Kang*b  

* Corresponding authors

a Department of Chemistry, Chonbuk National University, Jeonju 561-756, South Korea

b Department of Applied Chemistry, College of Applied Science, Kyung Hee University, Yongin-si, Gyeonggi-do 446-701, South Korea
E-mail: shkang@khu.ac.kr
Fax: +82 31 202 7337
Tel: +82 31 201 3349

Abstract

In a free solution of 10.0 mM Gly–Gly (pH 8.2), the flow directions of native-DNA and DNA molecules intercalated with the fluorescent dye YOYO-1 were reversed in the microchip channel. These results clearly showed that in a confined space and under specific environmental conditions, the fluorescent dye modified the original properties and behavior of the native-DNA molecule.

Graphical abstract: Native and fluorescent dye-dependent single-DNA molecule microchip dynamics as measured by differential interference contrast microscopy

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Article information

DOI
https://doi.org/10.1039/C1CC12911B
Article type
Communication
Submitted
18 May 2011
Accepted
27 Jun 2011
First published
13 Jul 2011

Chem. Commun., 2011,47, 9137-9139

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Native and fluorescent dye-dependent single-DNA molecule microchip dynamics as measured by differential interference contrast microscopy

D. Oh, S. Lee and S. H. Kang, Chem. Commun., 2011, 47, 9137 DOI: 10.1039/C1CC12911B

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