[Ru(η6-p-cymene)Cl2(pta)] (pta = 1,3,5-triaza-7-phosphatricyclo- [3.3.1.1]decane): a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells

Claire S. Allardyce; Paul J. Dyson; David J. Ellis; Sarah L. Heath

doi:10.1039/B104021A

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

[Ru(η⁶-p-cymene)Cl₂(pta)] (pta = 1,3,5-triaza-7-phosphatricyclo- [3.3.1.1]decane): a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells

Claire S. Allardyce,^a Paul J. Dyson,*^a David J. Ellis^a and Sarah L. Heath^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, The University of York, Heslington, York, UK
E-mail: pjd14@york.ac.uk

Abstract

The water soluble complex [Ru(η⁶-p-cymene)Cl₂(pta)] (pta = 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane), exhibits pH dependent DNA damage; the pH at which damage is greatest correlates well to the pH environment of cancer cells.

This article is part of the themed collections: ChemComm contributions to the United Nations Sustainable Development Goals and ChemComm 60th Anniversary Historic Papers from the United Kingdom

Download options Please wait...

Supplementary files

Crystal structure data TXT (38K)

Article information

DOI: https://doi.org/10.1039/B104021A
Article type: Communication
Submitted: 04 máj 2001
Accepted: 20 jún 2001
First published: 11 júl 2001

Download Citation

Chem. Commun., 2001, 1396-1397

Permissions

Request permissions

[Ru(η⁶-p-cymene)Cl₂(pta)] (pta = 1,3,5-triaza-7-phosphatricyclo- [3.3.1.1]decane): a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells

C. S. Allardyce, P. J. Dyson, D. J. Ellis and S. L. Heath, Chem. Commun., 2001, 1396 DOI: 10.1039/B104021A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications