Issue 44, 2021

Acridinone-based anion transporters

Abstract

The arrangement of hydrogen bond donors around a central lipophilic scaffold has proven to be a successful strategy in the development of potent chloride transporters. In this work, we revisit an acridinone 1,9-bis(thio)urea motif which had previously shown promise as an anion sensor and expand the series of compounds by appending a variety of electron-withdrawing groups to the peripheral phenyl moieties. High levels of activity were achieved by the most effective compounds in the series, which facilitated strictly electroneutral transport.

Graphical abstract: Acridinone-based anion transporters

Supplementary files

Article information

Article type
Paper
Submitted
06 aug 2021
Accepted
01 sep 2021
First published
13 sep 2021

Org. Biomol. Chem., 2021,19, 9659-9674

Acridinone-based anion transporters

D. A. McNaughton, L. K. Macreadie and P. A. Gale, Org. Biomol. Chem., 2021, 19, 9659 DOI: 10.1039/D1OB01545A

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