A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells

Shahi Imam Reja; Muskan Gupta; Neha Gupta; Vandana Bhalla; Puja Ohri; Gurcharan Kaur; Manoj Kumar

doi:10.1039/C6CC09127J

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A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells†

Shahi Imam Reja,‡^a Muskan Gupta,‡^b Neha Gupta,^a Vandana Bhalla,

^a Puja Ohri,^c Gurcharan Kaur*^b and Manoj Kumar*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, UGC Sponsored Centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar, Punjab, India
E-mail: mksharmaa@yahoo.co.in

^b Department of Biotechnology, Guru Nanak Dev University, Amritsar, Punjab, India

^c Department of Zoology, Guru Nanak Dev University, India

Abstract

A lysosome targetable naphthalimide based fluorescent probe (LyNC) has been designed and synthesized which detects hydrogen peroxide (H₂O₂) with high selectivity and sensitivity in brain tissues and in living nematodes among various ROS/RNS tested. Further, the probe LyNC was successfully employed in exogenous and endogenous imaging of H₂O₂ in living cell lines.

This article is part of the themed collections: Biological optical imaging and Most downloaded articles of 2017: Analytical Chemistry

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Article information

DOI: https://doi.org/10.1039/C6CC09127J
Article type: Communication
Submitted: 25 nov 2016
Accepted: 27 feb 2017
First published: 01 mar 2017

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Chem. Commun., 2017,53, 3701-3704

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A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells

S. I. Reja, M. Gupta, N. Gupta, V. Bhalla, P. Ohri, G. Kaur and M. Kumar, Chem. Commun., 2017, 53, 3701 DOI: 10.1039/C6CC09127J

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Chemical Communications

A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells†

Abstract

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A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells

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