Issue 2, 2016

Copper-catalyzed aminotrifluoromethylation of alkenes: a facile synthesis of CF3-containing lactams

Abstract

Copper-catalyzed aminotrifluoromethylation of alkenes using amides as nucleophiles has been developed. It provides a rapid and efficient access to a variety of CF3-containing lactams. The reaction proceeds under mild conditions with a good scope and functional group tolerance, offering a valuable method to prepare CF3-containing lactams that are of great potential in pharmaceuticals and agrochemicals.

Graphical abstract: Copper-catalyzed aminotrifluoromethylation of alkenes: a facile synthesis of CF3-containing lactams

Supplementary files

Article information

Article type
Research Article
Submitted
05 nov 2015
Accepted
05 dec 2015
First published
10 dec 2015

Org. Chem. Front., 2016,3, 222-226

Author version available

Copper-catalyzed aminotrifluoromethylation of alkenes: a facile synthesis of CF3-containing lactams

K. Shen and Q. Wang, Org. Chem. Front., 2016, 3, 222 DOI: 10.1039/C5QO00353A

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