A copper-catalyzed double carboxylation of o-alkynyl acetophenone using carbon dioxide to afford 1(3H)-isobenzofuranylidene dicarboxylic esters in good yields is described. The reaction proceeds via a carboxylation/intramolecular cyclization/carboxylation sequence. Alkyl-substituted substrates show much higher double carboxylation product selectivities than aryl-substituted substrates.
W. Zhang, M. Yang, X. Yang, L. Shi, H. Wang and X. Lu, Org. Chem. Front., 2016, 3, 217 DOI: 10.1039/C5QO00374A
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