Issue 42, 2014

Self-assembly of Cu(ii) with amyloid β19–20 peptide: relevant to Alzheimer's disease

Abstract

Amyloid-β (Aβ) peptide Aβ19–20 tends to self-assemble into well-ordered tubular structures under physiological conditions, while in the presence of equimolar Cu(II), they assembled into homogeneous microvesicles; a chelator can competitively bind to Cu(II) from the Cu(II)–Aβ19–20 complex, resulting in reforming of the peptide tubular structure.

Graphical abstract: Self-assembly of Cu(ii) with amyloid β19–20 peptide: relevant to Alzheimer's disease

Supplementary files

Article information

Article type
Communication
Submitted
28 mar 2014
Accepted
06 máj 2014
First published
08 máj 2014

RSC Adv., 2014,4, 21840-21843

Self-assembly of Cu(II) with amyloid β19–20 peptide: relevant to Alzheimer's disease

X. Shen, X. Deng and Y. Pang, RSC Adv., 2014, 4, 21840 DOI: 10.1039/C4RA02758B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements