Issue 15, 2001

[Ru(η6-p-cymene)Cl2 (pta)] (pta = 1,3,5-triaza-7-phosphatricyclo- [3.3.1.1]decane): a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells

Abstract

The water soluble complex [Ru(η6-p-cymene)Cl2(pta)] (pta = 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane), exhibits pH dependent DNA damage; the pH at which damage is greatest correlates well to the pH environment of cancer cells.

Supplementary files

Article information

Article type
Communication
Submitted
04 máj 2001
Accepted
20 jún 2001
First published
11 júl 2001

Chem. Commun., 2001, 1396-1397

[Ru(η6-p-cymene)Cl2 (pta)] (pta = 1,3,5-triaza-7-phosphatricyclo- [3.3.1.1]decane): a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells

C. S. Allardyce, P. J. Dyson, D. J. Ellis and S. L. Heath, Chem. Commun., 2001, 1396 DOI: 10.1039/B104021A

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