Issue 37, 2021

Copper-catalyzed N-arylation of pyrroles: an overview

Abstract

N-Arylated pyrroles have a wide range of applications in pharmaceuticals, the agrochemical industry and organic synthesis. They are intermediates for the formation of many biologically active compounds and natural products. Over the past decades, numerous protocols have been established for the efficient synthesis of N-aryl pyrroles, amongst which reactions using transition metal-based catalyst/mono- or bidentate ligand systems play an important role as they involve milder reaction conditions, affording excellent yields of the products. Amid these methods, the lion's share lies in copper catalysis. Many copper-based compounds are efficient as catalysts for organic synthesis, they are economical and nearly non-toxic. In this review, we focus on the copper-catalyzed C–N cross-coupling reactions of various aryl electrophiles with a range of nucleophilic pyrroles under various reaction conditions, covering the literature up to 2021.

Graphical abstract: Copper-catalyzed N-arylation of pyrroles: an overview

Article information

Article type
Perspective
Submitted
29 май 2021
Accepted
25 авг 2021
First published
25 авг 2021

New J. Chem., 2021,45, 17061-17076

Copper-catalyzed N-arylation of pyrroles: an overview

K. N. Hisana, C. M. A. Afsina and G. Anilkumar, New J. Chem., 2021, 45, 17061 DOI: 10.1039/D1NJ02638K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements