Issue 29, 2019

Synthesis of polysubstituted 3-aminoindenes via rhodium-catalysed [3+2] cascade annulations of benzimidates with alkenes

Abstract

A novel Rh-catalysed intermolecular [3+2] cascade cyclization of benzimidates and alkenes has been developed to assemble polysubstituted 3-aminoindenes. The target products are important building blocks for organic synthesis and drug discovery. Cheap and easily available α,β-unsaturated ketones or nitroalkenes are applied as coupling partners. Acyl or nitro groups are easily introduced to 3-aminoindenes at the C-2 position, which makes this reaction particularly attractive for further transformation to synthesize various important building blocks.

Graphical abstract: Synthesis of polysubstituted 3-aminoindenes via rhodium-catalysed [3+2] cascade annulations of benzimidates with alkenes

Supplementary files

Article information

Article type
Communication
Submitted
22 jan 2019
Accepted
12 mar 2019
First published
13 mar 2019

Chem. Commun., 2019,55, 4190-4193

Synthesis of polysubstituted 3-aminoindenes via rhodium-catalysed [3+2] cascade annulations of benzimidates with alkenes

B. Wu, Z. Yang, H. Zhang, L. Wang and X. Cui, Chem. Commun., 2019, 55, 4190 DOI: 10.1039/C9CC00567F

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