Issue 29, 2019
From the journal:

Chemical Communications

Dehydrocurvularin is a potent antineoplastic agent irreversibly blocking ATP-citrate lyase: evidence from chemoproteomics†

Zhangshuang Deng,abc   Nai-Kei Wong,d   Zhiyong Guo,b   Kun Zou,b   Youli Xiao ORCID logo e  and  Yiqing Zhou ORCID logo *ae  

* Corresponding authors

a School of Biotechnology and Food Engineering, Changshu Institute of Technology, Changshu, Jiangsu 215500, China
E-mail: zhyq2012@gmail.com

b Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, China

c Key Laboratory of Three Gorges Regional Plant Genetics & Germplasm Enhancement, China Three Gorges University, Yichang 443002, China

d Department of Infection Diseases, Shenzhen Third People's Hospital, The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen 518112, China

e CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China

Abstract

Natural-product macrolide 10,11-dehydrocurvularin (DCV) was revealed to be a potent irreversible inhibitor of ATP-citrate lyase (ACLY) via classical chemoproteomic profiling, which mechanistically illuminates the anti-cancer mode of action of DCV and its analogues.

Graphical abstract: Dehydrocurvularin is a potent antineoplastic agent irreversibly blocking ATP-citrate lyase: evidence from chemoproteomics

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Article information

DOI
https://doi.org/10.1039/C9CC00256A
Article type
Communication
Submitted
10 Jan 2019
Accepted
08 Mar 2019
First published
21 Mar 2019

Chem. Commun., 2019,55, 4194-4197

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Dehydrocurvularin is a potent antineoplastic agent irreversibly blocking ATP-citrate lyase: evidence from chemoproteomics

Z. Deng, N. Wong, Z. Guo, K. Zou, Y. Xiao and Y. Zhou, Chem. Commun., 2019, 55, 4194 DOI: 10.1039/C9CC00256A

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