Issue 23, 2012

General and efficient method for direct N-monomethylation of aromatic primary amines with methanol

Abstract

The direct N-monomethylation of aromatic primary amines, including arylamines, arylsulfonamides and amino-azoles, using methanol as a methylating agent has been accomplished in the presence of a [Cp*IrCl2]2/NaOH system. From both synthetic and environmental points of view, the reaction is highly attractive because of low catalyst loading, broad substrate scope and excellent selectivities.

Graphical abstract: General and efficient method for direct N-monomethylation of aromatic primary amines with methanol

Supplementary files

Article information

Article type
Paper
Submitted
18 jul 2012
Accepted
18 jul 2012
First published
26 jul 2012

RSC Adv., 2012,2, 8645-8652

General and efficient method for direct N-monomethylation of aromatic primary amines with methanol

F. Li, J. Xie, H. Shan, C. Sun and L. Chen, RSC Adv., 2012, 2, 8645 DOI: 10.1039/C2RA21487C

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