Issue 23, 2012
From the journal:

RSC Advances

Copper acetate monohydrate: a cheap but efficient oxidant for synthesizing multi-substituted indolizines from pyridinium ylides and electron deficient alkenes†

Huayou Hu,*ab   Junjun Feng,a   Yulan Zhu,a   Ning Gu*b  and  Yuhe Kan*a  

* Corresponding authors

a Department: Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huaian, P. R. China
E-mail: njuhhy@hotmail.com, kyh@hytc.edu.cn
Fax: (+)86(517)83525100-1
Tel: (+)86(517)83525100-4

b State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, P. R. China
E-mail: guning@seu.edu.cn

Abstract

We report a highly practical one-pot method for synthesizing multi-substituted indolizines from α-halide carbonyl compounds, pyridines and electron deficient alkenes in the presence of copper acetate monohydrate and sodium acetate in DMF. A variety of function groups are tolerable in standard reaction conditions, including aldehyde. 36 examples were presented. The yield of indolizine was from moderate to high. Furthermore, multi-substituted indolizines can be prepared at gram scale by this method.

Graphical abstract: Copper acetate monohydrate: a cheap but efficient oxidant for synthesizing multi-substituted indolizines from pyridinium ylides and electron deficient alkenes

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Article information

DOI
https://doi.org/10.1039/C2RA21213G
Article type
Paper
Submitted
19 Jun 2012
Accepted
06 Jul 2012
First published
14 Aug 2012

RSC Adv., 2012,2, 8637-8644

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Copper acetate monohydrate: a cheap but efficient oxidant for synthesizing multi-substituted indolizines from pyridinium ylides and electron deficient alkenes

H. Hu, J. Feng, Y. Zhu, N. Gu and Y. Kan, RSC Adv., 2012, 2, 8637 DOI: 10.1039/C2RA21213G

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