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Issue 23, 2012
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Copper acetate monohydrate: a cheap but efficient oxidant for synthesizing multi-substituted indolizines from pyridinium ylides and electron deficient alkenes

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Abstract

We report a highly practical one-pot method for synthesizing multi-substituted indolizines from α-halide carbonyl compounds, pyridines and electron deficient alkenes in the presence of copper acetate monohydrate and sodium acetate in DMF. A variety of function groups are tolerable in standard reaction conditions, including aldehyde. 36 examples were presented. The yield of indolizine was from moderate to high. Furthermore, multi-substituted indolizines can be prepared at gram scale by this method.

Graphical abstract: Copper acetate monohydrate: a cheap but efficient oxidant for synthesizing multi-substituted indolizines from pyridinium ylides and electron deficient alkenes

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Publication details

The article was received on 19 Jun 2012, accepted on 06 Jul 2012 and first published on 14 Aug 2012


Article type: Paper
DOI: 10.1039/C2RA21213G
RSC Adv., 2012,2, 8637-8644

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    Copper acetate monohydrate: a cheap but efficient oxidant for synthesizing multi-substituted indolizines from pyridinium ylides and electron deficient alkenes

    H. Hu, J. Feng, Y. Zhu, N. Gu and Y. Kan, RSC Adv., 2012, 2, 8637
    DOI: 10.1039/C2RA21213G

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