Themed collection Lab on a Chip Review Articles 2024

36 items
Open Access Perspective

Toward microfluidic continuous-flow and intelligent downstream processing of biopharmaceuticals

The concept of miniaturized biopharmaceutical downstream processing with AI-controlled continuous flow platforms is described to overcome limitations of conventional processes, potentially accelerating the development of novel biotherapeutics.

Graphical abstract: Toward microfluidic continuous-flow and intelligent downstream processing of biopharmaceuticals
From the themed collection: Lab on a Chip Review Articles 2024
Open Access Perspective

Development of wafer-scale multifunctional nanophotonic neural probes for brain activity mapping

We explore the development of multifunctional nanophotonic neural probes, integrating microelectrodes, optical emitters, and microfluidic channels for multimodal brain mapping.

Graphical abstract: Development of wafer-scale multifunctional nanophotonic neural probes for brain activity mapping
From the themed collection: Lab on a Chip Review Articles 2024
Open Access Perspective

Next generation microfluidics: fulfilling the promise of lab-on-a-chip technologies

In this perspective article, we present the state of the microfluidic field regarding current limitations and propose future directions and new approaches for the field to advance lab-on-a-chip technologies closer to translation and clinical use.

Graphical abstract: Next generation microfluidics: fulfilling the promise of lab-on-a-chip technologies
From the themed collection: Lab on a Chip Review Articles 2024
Perspective

From animal testing to in vitro systems: advancing standardization in microphysiological systems

For MPS technology to be effective not only innovation but standardization will be vital. This will require the consensus of all interested parties including academics, developers, regulatory agencies, metrology institutions, and stakeholders.

Graphical abstract: From animal testing to in vitro systems: advancing standardization in microphysiological systems
From the themed collection: Lab on a Chip Review Articles 2024
Perspective

Lab-on-a-chip models of the blood–brain barrier: evolution, problems, perspectives

A great progress has been made in the development and use of lab-on-a-chip devices to model and study the blood–brain barrier (BBB) in the last decade.

Graphical abstract: Lab-on-a-chip models of the blood–brain barrier: evolution, problems, perspectives
From the themed collection: Lab on a Chip Review Articles 2024
Open Access Perspective

Open microfluidics: droplet microarrays as next generation multiwell plates for high throughput screening

Droplet microarrays underpin novel experimentation across the biological and chemical sciences. This perspective explores operations and analysis with droplet microarrays, placing focus on a comparison to traditional multiwell plates.

Graphical abstract: Open microfluidics: droplet microarrays as next generation multiwell plates for high throughput screening
From the themed collection: Lab on a Chip Review Articles 2024
Open Access Perspective

Lipid vesicle-based molecular robots

A molecular robot, which is a system comprised of one or more molecular machines and computers, can execute sophisticated tasks in many fields that span from nanomedicine to green nanotechnology.

Graphical abstract: Lipid vesicle-based molecular robots
From the themed collection: Lab on a Chip HOT Articles 2023
Perspective

Microfluidic-assisted single-cell RNA sequencing facilitates the development of neutralizing monoclonal antibodies against SARS-CoV-2

We explore how microfluidic-based high-throughput single-cell RNA sequencing facilitates neutralizing monoclonal antibody development against SARS-CoV-2, and the potential improvement of therapeutic antibody discovery strategies.

Graphical abstract: Microfluidic-assisted single-cell RNA sequencing facilitates the development of neutralizing monoclonal antibodies against SARS-CoV-2
From the themed collection: Lab on a Chip Review Articles 2024
Open Access Tutorial Review

Direct laser writing-enabled 3D printing strategies for microfluidic applications

This Tutorial Review highlights strategies for leveraging the micron-to-submicron-scale additive manufacturing technique, “direct laser writing”, to enable 3D microfluidic technologies.

Graphical abstract: Direct laser writing-enabled 3D printing strategies for microfluidic applications
From the themed collection: Lab on a Chip Review Articles 2024
Open Access Tutorial Review

Microfluidic systems for infectious disease diagnostics

This review explores emerging microfluidic-based technologies incorporating innovative assay strategies for infectious disease diagnostics. Our classification scheme is based on the human body systems or pathogen transmission modes.

Graphical abstract: Microfluidic systems for infectious disease diagnostics
From the themed collection: Lab on a Chip Review Articles 2024
Tutorial Review

Heart-on-a-chip systems: disease modeling and drug screening applications

Heart-on-chip systems are one of the tools at the forefront in the race to develop alternative in vitro preclinical testing for disease modeling, drug toxicity and efficacy assessment. Further innovation and standardization will accelerate their use.

Graphical abstract: Heart-on-a-chip systems: disease modeling and drug screening applications
From the themed collection: Lab on a Chip Review Articles 2024
Tutorial Review

AI-enhanced biomedical micro/nanorobots in microfluidics

Although developed independently at the beginning, AI, micro/nanorobots and microfluidics have become more intertwined in the past few years which has greatly propelled the cutting-edge development in fields of biomedical sciences.

Graphical abstract: AI-enhanced biomedical micro/nanorobots in microfluidics
From the themed collection: Lab on a Chip Review Articles 2024
Open Access Critical Review

CRISPR for companion diagnostics in low-resource settings

New point-of-care tests (POCTs), which are especially useful in low-resource settings, are needed to expand screening capacity for diseases that cause significant mortality: tuberculosis, multiple cancers, and emerging infectious diseases.

Graphical abstract: CRISPR for companion diagnostics in low-resource settings
From the themed collection: Lab on a Chip Review Articles 2024
Open Access Critical Review

Modelling the innate immune system in microphysiological systems

Integration of an immune component moves the field closer to a physiologically relevant human-on-a-chip.

Graphical abstract: Modelling the innate immune system in microphysiological systems
From the themed collection: Lab on a Chip Review Articles 2024
Critical Review

Sample preparation and detection methods in point-of-care devices towards future at-home testing

This review covers recent advances in sample preparation and detection methods for point-of-care testing, aiming to accelerate progress towards at-home health monitoring for personalized healthcare in the future.

Graphical abstract: Sample preparation and detection methods in point-of-care devices towards future at-home testing
From the themed collection: Lab on a Chip Review Articles 2024
Critical Review

Bridging barriers: advances and challenges in modeling biological barriers and measuring barrier integrity in organ-on-chip systems

Biological barriers play key roles in homeostasis, disease physiology and drug delivery, highlighting a need for representative in vitro tools. We discuss advances and challenges in modeling and measuring barrier integrity in organ-on-chip systems.

Graphical abstract: Bridging barriers: advances and challenges in modeling biological barriers and measuring barrier integrity in organ-on-chip systems
From the themed collection: Lab on a Chip Review Articles 2024
Critical Review

Critical review of single-cell mechanotyping approaches for biomedical applications

Current approaches for mechanical measurements of single cells compromise between fidelity and throughput. Development of non-contact technologies and optimized theoretical modelling will advance mechanical characterisation of large cell populations.

Graphical abstract: Critical review of single-cell mechanotyping approaches for biomedical applications
From the themed collection: Lab on a Chip Review Articles 2024
Critical Review

Integrating microfluidics and synthetic biology: advancements and diverse applications across organisms

Synthetic biology and microfluidics merge to propel the design of various biological systems like bacteria, yeast, fungi, mammalian cells, or cell-free systems for targeted functions. This synergy accelerates synthetic biology applications across these diverse hosts, showcased in this review.

Graphical abstract: Integrating microfluidics and synthetic biology: advancements and diverse applications across organisms
From the themed collection: Lab on a Chip Review Articles 2024
Critical Review

Actuation for flexible and stretchable microdevices

This review paper provides a comprehensive overview of the state-of-the-art actuation mechanisms for flexible and stretchable microdevices.

Graphical abstract: Actuation for flexible and stretchable microdevices
From the themed collection: Lab on a Chip Review Articles 2024
Critical Review

Recent developments and future perspectives of microfluidics and smart technologies in wearable devices

Wearable devices are increasingly popular in health monitoring, diagnosis, and drug delivery. Advances allow real-time analysis of biofluids like sweat, tears, saliva, wound fluid, and urine.

Graphical abstract: Recent developments and future perspectives of microfluidics and smart technologies in wearable devices
From the themed collection: Lab on a Chip Review Articles 2024
Critical Review

Understanding organotropism in cancer metastasis using microphysiological systems

Organotropism is an important concept to explain the process of cancer metastasis. In this paper, we introduce microphysiological systems with simultaneous physiological relevance and high throughput to recapitulate the series of cancer progression.

Graphical abstract: Understanding organotropism in cancer metastasis using microphysiological systems
From the themed collection: Lab on a Chip Review Articles 2024
Open Access Critical Review

Microfluidic approaches in microbial ecology

Here we explore the use of microfluidic systems in microbial ecology, describing applications ranging from the investigation of single-cell behaviors to the imaging of complex three-dimensional biofilms.

Graphical abstract: Microfluidic approaches in microbial ecology
From the themed collection: Lab on a Chip Review Articles 2024
Critical Review

Twenty years of islet-on-a-chip: microfluidic tools for dissecting islet metabolism and function

Islet-on-a-chip devices have the power to measure pancreatic islet metabolism from donor and engineered islets. These measurements could be used to determine healthy islets for the treatment of type 1 diabetes.

Graphical abstract: Twenty years of islet-on-a-chip: microfluidic tools for dissecting islet metabolism and function
From the themed collection: Lab on a Chip Review Articles 2024
Critical Review

Recent advances in micro-physiological systems for investigating tumor metastasis and organotropism

MPS technology holds great potential for studying complex metastasis organotropism. It effectively simulates the dynamic interactions between distinct organ environments and the tumor cells, capturing both their inter- and intra-tumor heterogeneity.

Graphical abstract: Recent advances in micro-physiological systems for investigating tumor metastasis and organotropism
From the themed collection: Lab on a Chip Review Articles 2024
Open Access Critical Review

Progress in developing microphysiological systems for biological product assessment

This review delves into microphysiological systems, miniature physiological environments used to evaluate biological products, reducing the need for animal experimentation. We consider their benefits as well as persistent challenges in material selection/fabrication and reproducibility.

Graphical abstract: Progress in developing microphysiological systems for biological product assessment
From the themed collection: Lab on a Chip Review Articles 2024
Open Access Critical Review

Lab-on-chip technologies for exploring the gut–immune axis in metabolic disease

Further development of lab-on-chip platforms is required to create an environment capable of hosting more complex microbiota and immune cells.

Graphical abstract: Lab-on-chip technologies for exploring the gut–immune axis in metabolic disease
From the themed collection: Lab on a Chip Review Articles 2024
Critical Review

Revolutionizing targeting precision: microfluidics-enabled smart microcapsules for tailored delivery and controlled release

Microfluidic-enabled smart microcapsules as delivery systems from droplet fabrication to tailored delivery and controlled release.

Graphical abstract: Revolutionizing targeting precision: microfluidics-enabled smart microcapsules for tailored delivery and controlled release
From the themed collection: Lab on a Chip Review Articles 2024
Critical Review

High-throughput microfluidic systems accelerated by artificial intelligence for biomedical applications

This review outlines the current advances of high-throughput microfluidic systems accelerated by AI. Furthermore, the challenges and opportunities in this field are critically discussed as well.

Graphical abstract: High-throughput microfluidic systems accelerated by artificial intelligence for biomedical applications
From the themed collection: Lab on a Chip Review Articles 2024
Open Access Critical Review

Harvesting and manipulating sweat and interstitial fluid in microfluidic devices

This review focuses on microfluidic techniques for sampling, sensing, and managing of sweat and interstitial fluid (ISF).

Graphical abstract: Harvesting and manipulating sweat and interstitial fluid in microfluidic devices
From the themed collection: Lab on a Chip Review Articles 2024
Critical Review

Expanding CAR-T cell immunotherapy horizons through microfluidics

This review outlines Chimeric antigen receptor (CAR)-T cell manufacturing, highlights challenges, and explores successful microfluidic approaches and related technologies to address them.

Graphical abstract: Expanding CAR-T cell immunotherapy horizons through microfluidics
From the themed collection: Lab on a Chip Review Articles 2024
Critical Review

Development and future of droplet microfluidics

This review introduces the development of droplet microfluidics by explaining the physical mechanisms of droplet generation, discussing various approaches in manipulating droplets, and summarizing key applications in material science and biological analyses.

Graphical abstract: Development and future of droplet microfluidics
From the themed collection: Lab on a Chip Review Articles 2024
Open Access Critical Review

Microfluidic synthesis of radiotracers: recent developments and commercialization prospects

Current radiotracer production approaches restrict clinicians' access to a wide range of targeted probes. In this review, we assess the current state of microfluidic synthesis platforms with a view towards future dose-on-demand production.

Graphical abstract: Microfluidic synthesis of radiotracers: recent developments and commercialization prospects
From the themed collection: Lab on a Chip Review Articles 2024
Open Access Critical Review

Innovative electrode and chip designs for transendothelial electrical resistance measurements in organs-on-chips

This review summarizes innovative chip and electrode designs that use transendothelial electrical resistance (TEER) measurements to assess biological barrier properties (figure created with Adobe Firefly).

Graphical abstract: Innovative electrode and chip designs for transendothelial electrical resistance measurements in organs-on-chips
From the themed collection: Lab on a Chip Review Articles 2024
Open Access Critical Review

Antibodies, repertoires and microdevices in antibody discovery and characterization

Essential in treating numerous diseases, novel therapeutic antibody candidates are needed. This critical review examines recent advances in microdevices and the challenges associated with candidate discovery and characterization.

Graphical abstract: Antibodies, repertoires and microdevices in antibody discovery and characterization
From the themed collection: Lab on a Chip Review Articles 2024
Open Access Critical Review

Microfluidics in environmental analysis: advancements, challenges, and future prospects for rapid and efficient monitoring

This review highlights the latest advancements in microfluidic devices in environmental monitoring during the last 5 years. We also emphasize the current limitations in the devices and propose effective strategies to improve environmental monitoring.

Graphical abstract: Microfluidics in environmental analysis: advancements, challenges, and future prospects for rapid and efficient monitoring
From the themed collection: Lab on a Chip Review Articles 2024
Critical Review

Microfluidic synthesis of lipid-based nanoparticles for drug delivery: recent advances and opportunities

The current landscape of microfluidic technologies for lipid nanoparticle production, size control, scaling, and nanomedicine post-processing is described in a review of this evolving field.

Graphical abstract: Microfluidic synthesis of lipid-based nanoparticles for drug delivery: recent advances and opportunities
From the themed collection: Lab on a Chip Review Articles 2024
36 items

About this collection

This themed collection features recent review articles published in Lab on a Chip.

Spotlight

Advertisements