Themed collection Green Synthesis

HIPE templated scaffolds of poly(ε-caprolactone).

This article summarizes recent examples of synthesis of active ingredients involving electrochemical steps and discusses the merits of electroorganic synthesis in terms of green chemistry.

We highlight the recent advances in the field of organic photoredox catalytic cascade reactions and describe their mechanisms and applications in organic synthesis.

The application of immobilised enzymes in flow allows for process intensification, reduced reactor volumes and improved safety.

Developing (chemo)enzymatic cascades is very attractive for green synthesis, because they streamline multistep synthetic processes.

More than 100 useful ‘xylochemicals’ and their natural origins are offered combined with an overview of comparative petro- and xylochemical approaches to synthetic chemistry.

Recent progress in sustainable approaches using (1,n) annulation for the synthesis of stereo-selective cycloalkanes, cycloalkenes and N-heterocycles is discussed.

This feature article summarises the recent progress in the visible light photoredox organic reactions of N-(acyloxy)phthalimide and oxime derivatives via the cleavage of N–O bonds.

This feature article aims to summarize the exciting advances in organocatalytic enantioselective reactions involving prochiral carbocationic intermediates.

Photosynthesis and electrosynthesis enable the “green” upcycling of SO₂ to value-added products.

Different strategies and new P-radical precursor induced C–P bond formation by visible light photocatalysis were summarized.

Drawing on independent work carried out by academic and industrial researchers using the immobilized TEMPO catalyst SiliaCat TEMPO, in this study, we show how shifting the carboxylation process mediated by TEMPO in solution to a process mediated by the above-mentioned hybrid sol–gel catalyst allows the synthesis of insoluble polysaccharide nanofibers of superior quality, eliminating waste.

Bimetallic Pt–Cu alloy nanoparticles were used as highly active and selective catalysts for the oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) under base-free conditions.

A hybrid one-pot tandem protocol combining s-block reagents with enzymes (laccase from Trametes versicolor), in aqueous media, at room temperature and under air, is disclosed.

Bio-catalytic reactions involving ene-reductases (EREDs) in tandem with chemo-catalysis in water can be greatly enhanced by the presence of nanomicelles derived from the surfactant TPGS-750-M.

Intensified continuous extraction and recovery of switchable hydrophilicity solvents is presented, offering an energy-efficient solvent utilization strategy for green synthesis.

The photocatalytic single-electron oxidation of oxaziridines increases their acidity, thus facilitating the application of a weak base feasible for converting oxaziridines to amides.

An energy-efficient adsorptive molecular sieving strategy is reported using a crystalline trianglimine macrocycle to separate the elusive m-xylene isomer with over 91% purity.

The tropylium ion serves as an excellent and environmentally-benign catalyst for the Ritter reaction.

The ABNO@PMO-IL-Br material obtained by anchoring 9-azabicyclo[3.3.1]nonane-3-one N-oxyl within the mesopores of PMO with bridged imidazolium groups is a robust bifunctional catalyst for the metal-free aerobic oxidation of a wide variety of alcohols under oxygen balloon reaction conditions.

Alcoholysis of propylene oxide is achieved over azolate ionic liquids at room temperature by hydrogen-bonding catalysis, accessing glycol ethers in moderate to high yields with selectivity of >99%.

Radical fluoroalkylation of alkenes has been developed by electrochemical reduction of fluoroalkyl sulfones.

Immobilization of lipase and palladium nanoparticles onto cellulose creates an artificial plant cell wall structure for dynamic kinetic resolution.

Herein, we describe a protocol for electrochemical cathode reduction to generate trifluoromethyl radicals.

The site-selective N¹-alkylation of benzotriazoles with diazoalkanes is achieved using 10 mol% of B(C₆F₅)₃ as a catalyst.

A robust and sustainable C(sp²)–C(sp³) cross-electrophile coupling was developed via nickel/copper synergistic catalysis under micellar conditions.

An alginate-confined peroxygenase-CLEA has been prepared for the stereoselective epoxidation of cis-β-methylstyrene under non-aqueous reaction conditions. Product titres of up to 48 mM and excellent enzyme turnovers of 96 000 have been achieved.

A lignocellulose-to-chemicals valorization chain is presented, wherein lignin oligomers obtained from reductive catalytic fractionation are used to synthesize BPA-free epoxy resins.

The widespread presence of secondary amines in agrochemicals, pharmaceuticals, natural products, and small-molecule biological probes has inspired efforts to streamline the synthesis of molecules with this functional group.

Organic electrosynthesis enables the formation of symmetrical sulfamides directly from anilines and SO₂ mediated by iodide.