Issue 99, 2022

A dynamic reversible phenylboronic acid sensor for real-time determination of protein–carbohydrate interactions on living cancer cells

Abstract

Real-time detection of glycosylation on label-free cancer cell surfaces is of significance for the diagnosis and treatment of cancer. In this work, we have successfully developed a novel dynamic reversible sensor based on pH-sensitive phenylboronic esters to determine in real-time the binding kinetics of protein–carbohydrate interactions on suspension cancer cell surfaces using a quartz crystal microbalance (QCM) technique.

Graphical abstract: A dynamic reversible phenylboronic acid sensor for real-time determination of protein–carbohydrate interactions on living cancer cells

Supplementary files

Article information

Article type
Communication
Submitted
25 okt 2022
Accepted
14 nov 2022
First published
14 nov 2022

Chem. Commun., 2022,58, 13731-13734

A dynamic reversible phenylboronic acid sensor for real-time determination of protein–carbohydrate interactions on living cancer cells

Q. Song, Q. Li, S. Chao, X. Chen, R. Li, Y. Lu, T. Aastrup and Z. Pei, Chem. Commun., 2022, 58, 13731 DOI: 10.1039/D2CC05788C

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