Issue 99, 2022

Sticktight-inspired PEGylation for low-fouling coatings

Abstract

Polyethylene glycol (PEG) has been widely used for modifying surfaces to reduce non-specific interactions with biomolecules, microorganisms, and cells. Herein, we report a sticktight-inspired PEGylation strategy to fabricate low-fouling coatings. The influence of PEG molecular architectures on the PEG density and biological adhesion were studied. Notably, an increase in the number of arms resulted in improved surface PEGylation and an improved antifouling ability against the adhesion of proteins, mammalian cells and bacteria. The molecular architecture-dependent PEGylation strategy is an attractive approach for developing advanced low-fouling coatings.

Graphical abstract: Sticktight-inspired PEGylation for low-fouling coatings

Supplementary files

Article information

Article type
Communication
Submitted
06 Sep 2022
Accepted
11 Nov 2022
First published
11 Nov 2022

Chem. Commun., 2022,58, 13735-13738

Sticktight-inspired PEGylation for low-fouling coatings

K. Zhao, M. Li, P. Zhang and J. Cui, Chem. Commun., 2022, 58, 13735 DOI: 10.1039/D2CC04938D

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