Issue 36, 2022

Reengineering of cancer cell surface charges can modulate cell migration

Abstract

The ability to modulate the cell surface structure provides a powerful tool to understand fundamental processes and also to elicit desired cellular responses. Here we report the development of a new class of ‘clickable labels’ to reengineer the cell surface charges of live cells. The method relies on the use of metabolic oligosaccharide engineering (MOE) combined with chemo selective labeling of cell surface azido-containing sialic acids with dibenzocyclooctyne (DBCO) ionic-probes. Using this strategy, we demonstrate that reducing the negative charge induced by the overexpression of cell surface sialic acids in cancer cells leads to a reduction in cell migration without affecting drug supceptibility.

Graphical abstract: Reengineering of cancer cell surface charges can modulate cell migration

Supplementary files

Article information

Article type
Communication
Submitted
21 jan 2022
Accepted
06 apr 2022
First published
06 apr 2022
This article is Open Access
Creative Commons BY license

Chem. Commun., 2022,58, 5522-5525

Reengineering of cancer cell surface charges can modulate cell migration

M. Ghirardello, R. Shyam and M. C. Galan, Chem. Commun., 2022, 58, 5522 DOI: 10.1039/D2CC00402J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements