Issue 36, 2022

Hydrogen sulphide-triggered theranostic prodrugs based on the dynamic chemistry of tetrazines

Abstract

Dynamic nucleophilic aromatic substitution of tetrazines (SNTz) has been employed to build theranostic prodrugs that are activated by hydrogen sulfide. H2S is typically found in high concentrations in some kinds of cancer cells and it is able to trigger the disassembly of tetrazine prodrugs. In such a way, a dual release of drugs and/or fluorescent compounds can be selectively triggered.

Graphical abstract: Hydrogen sulphide-triggered theranostic prodrugs based on the dynamic chemistry of tetrazines

Supplementary files

Article information

Article type
Communication
Submitted
25 Feb 2022
Accepted
08 Apr 2022
First published
08 Apr 2022
This article is Open Access
Creative Commons BY license

Chem. Commun., 2022,58, 5518-5521

Hydrogen sulphide-triggered theranostic prodrugs based on the dynamic chemistry of tetrazines

M. D. Perretti, Y. Pérez-Pérez, K. Soler-Carracedo, E. Martín-Encinas, C. Alonso, J. Scoccia and R. Carrillo, Chem. Commun., 2022, 58, 5518 DOI: 10.1039/D2CC01170K

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