Issue 39, 2021

Cation-chloride cotransport mediated by an ion pair transporter

Abstract

Ion transport mediated by an ion pair receptor 1 bearing both cation and anion binding sites is presented. The ion pair binding property was revealed by means of 1H NMR titrations in organic solutions and X-ray analysis in the solid state. Single crystal structures demonstrated that 1 and CaI2 formed a solvent-separated ion-pair complex with two iodides each interacting with a triazine ring through anion–π interactions, whereas the calcium ion is bound by a pentaethylene glycol moiety. The ion transport activity was studied by monitoring the efflux of ions from salt-loaded EYPC large unilamellar vesicles (EYPC-LUVs) using ion selective electrodes. Chloride transport across the membrane mediated by the ion pair receptor through K+/Cl or Na+/Cl cotransport with a selectivity towards the K+/Cl symport was realized.

Graphical abstract: Cation-chloride cotransport mediated by an ion pair transporter

Supplementary files

Article information

Article type
Paper
Submitted
17 aug 2021
Accepted
15 sep 2021
First published
15 sep 2021

Org. Biomol. Chem., 2021,19, 8586-8590

Cation-chloride cotransport mediated by an ion pair transporter

J. Zhu, X. Wang, J. Luo, Y. Ao, Q. Wang and D. Wang, Org. Biomol. Chem., 2021, 19, 8586 DOI: 10.1039/D1OB01617B

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