Issue 26, 2017

A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells

Abstract

A lysosome targetable naphthalimide based fluorescent probe (LyNC) has been designed and synthesized which detects hydrogen peroxide (H2O2) with high selectivity and sensitivity in brain tissues and in living nematodes among various ROS/RNS tested. Further, the probe LyNC was successfully employed in exogenous and endogenous imaging of H2O2 in living cell lines.

Graphical abstract: A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells

Supplementary files

Article information

Article type
Communication
Submitted
25 nov 2016
Accepted
27 feb 2017
First published
01 mar 2017

Chem. Commun., 2017,53, 3701-3704

A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells

S. I. Reja, M. Gupta, N. Gupta, V. Bhalla, P. Ohri, G. Kaur and M. Kumar, Chem. Commun., 2017, 53, 3701 DOI: 10.1039/C6CC09127J

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