Issue 10, 2016

Towards taxane analogues synthesis by dienyne ring closing metathesis

Abstract

Herein we report the facile construction of taxadiene analogues by ring closing metathesis of dienynes built on a cyclohexenone with a natural configuration at C1 and its further transformation to incorporate most of the key functional groups of taxol.

Graphical abstract: Towards taxane analogues synthesis by dienyne ring closing metathesis

Supplementary files

Article information

Article type
Research Article
Submitted
01 jul 2016
Accepted
17 aug 2016
First published
18 aug 2016

Org. Chem. Front., 2016,3, 1331-1336

Towards taxane analogues synthesis by dienyne ring closing metathesis

S. Pérez-Estrada, N. Sayar and J. R. Granja, Org. Chem. Front., 2016, 3, 1331 DOI: 10.1039/C6QO00321D

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