Aliphatic C–H azidation through a peroxydisulfate induced radical pathway

Abstract

A persulfate induced radical process to transform aliphatic tertiary C–H bonds into organic azides under transition-metal-free conditions has been developed. This method exhibits good chemo- and regioselectivity. A wide range of functional groups, including esters, halogens, azides, and dipeptides, are all tolerated well through the radical pathway, thus expanding the potential application of this method.