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Issue 10, 2016
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Aliphatic C–H azidation through a peroxydisulfate induced radical pathway

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Abstract

A persulfate induced radical process to transform aliphatic tertiary C–H bonds into organic azides under transition-metal-free conditions has been developed. This method exhibits good chemo- and regioselectivity. A wide range of functional groups, including esters, halogens, azides, and dipeptides, are all tolerated well through the radical pathway, thus expanding the potential application of this method.

Graphical abstract: Aliphatic C–H azidation through a peroxydisulfate induced radical pathway

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Publication details

The article was received on 30 May 2016, accepted on 10 Aug 2016 and first published on 18 Aug 2016


Article type: Research Article
DOI: 10.1039/C6QO00237D
Citation: Org. Chem. Front., 2016,3, 1326-1330

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    Aliphatic C–H azidation through a peroxydisulfate induced radical pathway

    X. Li and Z. Shi, Org. Chem. Front., 2016, 3, 1326
    DOI: 10.1039/C6QO00237D

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