Issue 5, 2023

A robust and efficient lipase based nanobiocatalyst for phenothiazinyl-ethanol resolution

Abstract

A new robust, active and selective biocatalyst was prepared by entrapment of lipase B from Candida antarctica into polyvinyl alcohol–chitosan nanofibers. The influence of the most important process parameters on biocatalyst activity and selectivity was studied and the substrate domain was finally investigated. The developed biocatalyst presents high activity and selectivity and excellent stability for synthetic application, preserving more that 95% activity even after 10 reaction cycles, and is efficient for the enzymatic kinetic resolution of nine racemic phenothiazinyl-ethanols, especially for N-ethyl and N-butyl derivatives, bulky substrates with high relevance as chiral building blocks.

Graphical abstract: A robust and efficient lipase based nanobiocatalyst for phenothiazinyl-ethanol resolution

Supplementary files

Article information

Article type
Paper
Submitted
23 nov 2022
Accepted
03 feb 2023
First published
06 feb 2023

React. Chem. Eng., 2023,8, 1109-1116

A robust and efficient lipase based nanobiocatalyst for phenothiazinyl-ethanol resolution

C. Spelmezan, G. Katona, L. C. Bencze, C. Paizs and M. I. Toşa, React. Chem. Eng., 2023, 8, 1109 DOI: 10.1039/D2RE00515H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements