Issue 70, 2022

Design of high-avidity multivalent ligand structures that target cells with high ligand economy

Abstract

Novel cell-targeting ligand structures are constructed with a spikey core scaffold, where multiple copies of coiled-coil peptide nanorods are conjugated on the surface of a peptide nanosheet. Clustering of carbohydrate and aptamer ligands at the end of the coiled coils optimizes ligand accessibility to cell-surface receptors. Display of the ligand-coil conjugates on the nanosheet generates a patchy ligand pattern bearing two levels of multivalency. With the ligand-scaffold system, high-avidity cell targeting is realized using fewer ligands than ever, which facilitates future applications in cell detection and drug delivery.

Graphical abstract: Design of high-avidity multivalent ligand structures that target cells with high ligand economy

Supplementary files

Article information

Article type
Communication
Submitted
11 jun 2022
Accepted
08 aug 2022
First published
08 aug 2022

Chem. Commun., 2022,58, 9802-9805

Design of high-avidity multivalent ligand structures that target cells with high ligand economy

Q. Fang, P. Guo, Y. Zeng, C. Wang, T. Jiang and Y. Jiang, Chem. Commun., 2022, 58, 9802 DOI: 10.1039/D2CC03296A

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