Themed collection Metallomics Recent Open Access Articles

Taking a systems analytical approach to systems biology questions requires a network of multidimensional analytical tools to illuminate the many different functional and structural aspects of metals in biology.

In this review, we highlight the importance of a Cu imbalance in the pathogenesis of several chronic inflammatory diseases.

ICD enhances antigenicity from dying cancer cells, which leads to antitumor immunity. We show for the first time that a ruthenium-complex induces the ICD signature in a 3D model.

Coordination environment and conformational consequences of Cu(I) binding at Met-X₃-Met site of AcαS.

Adipose and muscle tissue – so far underestimated – contribute to the total Cd burden. Cd distribution in testis and kidney correlates with the histologic blood-testis-barrier and renal excretion, respectively.

Interdisciplinary study of the cellular transport and metabolism of the organo-osmium complex FY26 in cancer cells towards its clinical development.

Resistance development is a major obstacle for platinum-based chemotherapy, with the anticancer drug oxaliplatin being no exception.

Zinc transporter ZIP7 activates key downstream signalling pathways and is correlated with important clinicopathological parameters that are associated with endocrine resistance.

Using a yeast assay, we identified the roles of ATP7B's six metal-binding domains in internal copper transport and soluble chaperone capacity.

Targeting the Cu chaperone ATOX1 in BRAF^V600E-driven melanoma dampens cell growth due in part by reducing oncogenic MAPK signal transduction.

Atox1–MBD4 interaction mediates the in-cell Cu(I) concentration.

Recent research performed on volunteers and patients suggested that diet, health, and basal metabolic rates (BMR) are factors controlling the bodily Zn isotope compositions (isotopic homeostasis).

Substitutions with lanthanides reveal a high sensitivity of cadherin structure, dynamics and function to metal ion chemistry.

Friendreich's ataxia skin cells are highly sensitive to ultraviolet A due to their high levels of mitochondrial redox-active iron.

Dinuclear ruthenium complexes inhibit N. caninum and specifically target the parasite mitochondria.

Iron(II) clathrochelates are protein-sensitive CD reporters able to discriminate proteins of similar structure (HSA and BSA) and reflect the transitions of protein conformation.

Pathogenic Staphylococcus aureus respond to copper stress by altering central carbon metabolism in response to a specific inhibition of the glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase.

X-ray fluorescence microscopy reveals unique elemental signatures within sub-populations of hippocampal pyramidal neurons.

Microorganisms have to adapt their metabolism to the requirements of their ecological niche to avoid iron shortage as well as iron toxicity.

Oikopleura dioica has the longest metallothionein described so far, made of repeats generated by a modular and step-wise evolution.