Issue 10, 2016
From the journal:

Organic Chemistry Frontiers

Towards taxane analogues synthesis by dienyne ring closing metathesis†‡

S. Pérez-Estrada,a   N. Sayar ORCID logo a  and  J. R. Granja ORCID logo *a  

* Corresponding authors

a Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
E-mail: juanr.granja@usc.es

Abstract

Herein we report the facile construction of taxadiene analogues by ring closing metathesis of dienynes built on a cyclohexenone with a natural configuration at C1 and its further transformation to incorporate most of the key functional groups of taxol.

Graphical abstract: Towards taxane analogues synthesis by dienyne ring closing metathesis

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Article information

DOI
https://doi.org/10.1039/C6QO00321D
Article type
Research Article
Submitted
01 jul 2016
Accepted
17 aug 2016
First published
18 aug 2016

Org. Chem. Front., 2016,3, 1331-1336

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Towards taxane analogues synthesis by dienyne ring closing metathesis

S. Pérez-Estrada, N. Sayar and J. R. Granja, Org. Chem. Front., 2016, 3, 1331 DOI: 10.1039/C6QO00321D

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