Issue 24, 2023

Targeting endosomal receptors, a new direction for polymers in nanomedicine

Abstract

In this perspective, we outline a new opportunity for exploiting nanoparticle delivery of antagonists to target G-protein coupled receptors localized in intracellular compartments. We discuss the specific example of antagonizing endosomal receptors involved in pain to develop long-lasting analgesics but also outline the broader application potential of this delivery approach. We discuss the materials used to target endosomal receptors and indicate the design requirements for future successful applications.

Graphical abstract: Targeting endosomal receptors, a new direction for polymers in nanomedicine

Article information

Article type
Perspective
Submitted
27 jan 2023
Accepted
10 mei 2023
First published
22 mei 2023

J. Mater. Chem. B, 2023,11, 5390-5399

Targeting endosomal receptors, a new direction for polymers in nanomedicine

P. D. Ramirez-Garcia, N. A. Veldhuis, N. W. Bunnett and T. P. Davis, J. Mater. Chem. B, 2023, 11, 5390 DOI: 10.1039/D3TB00156C

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